An antibody library is an essential and important platform in the field of discovery of antibody therapeutics. MOGAM has generated two formats of antibody libraries with Fab and heavy chain variable domains (VH). The human-like synthetic Fab library constructed by combining the high throughput sequencing (HT-sequencing) information about the human variable gene repertoire, and a novel approach to design synthetic codons. We confirmed that the design of CDRs was precisely embodied in the library with an expected quality by HT sequencing. The VH domain library was constructed using rationally controlled CDRs to overcome the lack of binding sites and further engineered to have high levels of thermodynamic stability, soluble expression, and reversible folding.